Guaiphenesin Cough Syrup in Pune ( गुआइफेनेसिन सिरप, पुणे)

192x 60ml, 144x100ml COMPOSITION: Each 5 ml contains DesloratadineB.P.2.5 mgAmbroxol hydrochlorideI.P.30 mgGuaiphenesinI.P.50 mgMentholI.P.1 mgIn a flavoured syrupy base Colour: Ponceau 4R DESCRIPTION: Ambroxol is the metabolite of bromhexine and a mucolytic agent. Ambroxol acts as secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. Guaiphenesin is an expectorant that increases respiratory tract fluid secretions and helps loosen phlegm and bronchial secretions. Desloratadine is a non-sedating long-acting antihistamine with selective peripheral H1-receptor antagonist activity, which has demonstrated antiallergic, antihistaminic, and anti-inflammatory activity. MECHANISM OF ACTION: Ambroxol facilitates mucociliary clearance by intensifying the motion of the cilia present on the ciliated respiratory epithelium. By reducing the viscosity of secretions, guaiphenesin increases the efficiency of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway. Desloratadine is a non-sedating, long-acting histamine antagonist with selective peripheral H1-receptor antagonist activity. After oral administration, desloratadine selectively blocks peripheral histamine H1-receptors because the substance is excluded from entry to the central nervous system. Desloratadine has demonstrated antiallergic properties from in vitro studies. These include inhibiting the release of proinflammatory cytokines such as IL-4, IL-6, IL-8, and IL-13 from human mast cells/basophils, as well as inhibition of the expression of the adhesion molecule P-selectin on endothelial cells. INDICATIONS: Whooping cough, smokers dry cough, chronic cough and post-surgical cough. CONTRA-INDICATIONS: There are no absolute contraindications but in patients with gastric ulceration relative caution should be observed. Use cautiously in pregnancy lactation. Children 6 months to 11 years of age with renal impairment. SIDE EFFECTS: Drowsiness, dry mouth, sore throat, tiredness. Seek medical attention right away if any of these side effects occur when using this drug: Severe allergic reactions (rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips, or tongue, unusual hoarseness), dark urine; fainting, fever, irregular heartbeat, mental or mood changes, seizure, severe or persistent dizziness, shortness of breath, yellowing of the eyes or skin. DOSAGE: As directed by the physician. STORAGE: Store in a cool & dry place, Recap the bottle tightly after each use. SHAKE WELL BEFORE USE

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